• 双歧杆菌三联活菌散在儿童消化性溃疡中的应用效果分析
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    中文关键词:  消化性溃疡  儿童  双歧杆菌三联活菌散  幽门螺杆菌
    英文关键词:Peptic ulcer  Children  Bifidobacterium triple live powder  Helicobacter pylori
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    作者单位邮编
    阮倩倩* 南阳市中心医院 473000
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    中文摘要:
          目的 分析双歧杆菌三联活菌散在儿童消化性溃疡中的应用效果。方法 选取2021年3月至2024年3月收治的94例儿童消化性溃疡患者为研究对象,按照随机数表法分为观察组与对照组,每组47例。观察组在四联疗法基础上联合应用双歧杆菌三联活菌散,对照组单纯开展四联疗法治疗,观察两组患儿血清学指标、肠道菌群情况、幽门螺杆菌感染及清除情况、临床疗效。结果 治疗2、4周后,观察组患儿IFN-γ、TNF-α、CRP水平均低于对照组(P<0.05),TGF-β1、bFGF、VEGF水平均高于对照组(P<0.05),产气荚膜梭菌含量低于对照组,乳酸菌、双歧杆菌含量以及B/E值高于对照组(P<0.05);治疗4周后,幽门螺杆菌感染根除率以及临床疗效与对照组无明显差异(P>0.05)。结论 在四联疗法基础上联合应用双歧杆菌三联活菌散,有利于抑制消化性溃疡创面炎症反应、提升生长因子水平、改善肠道菌群结构,为溃疡愈合创造有利条件,值得临床推广。
    英文摘要:
          Objective: To analyze the application effect of Bifidobacterium triple live powder in children with peptic ulcers. Method: 94 pediatric patients with peptic ulcers admitted from March 2021 to March 2024 were selected as the study subjects. They were randomly divided into an observation group and a control group using a random number table method, with 47 cases in each group. The observation group received a combination of Bifidobacterium triple live powder and quadruple therapy, while the control group received only quadruple therapy. The serum indicators, intestinal microbiota, Helicobacter pylori infection and clearance, and clinical efficacy of the two groups of children were observed. After 2 and 4 weeks of treatment, the levels of IFN - γ, TNF - α, and CRP in the observation group were lower than those in the control group (P<0.05), while the levels of TGF - β 1, bFGF, and VEGF were higher than those in the control group (P<0.05). The content of Clostridium perfringens was lower than that in the control group, while the content of lactic acid bacteria, bifidobacteria, and B/E values were higher than those in the control group (P<0.05); After 4 weeks of treatment, there was no significant difference in the eradication rate and clinical efficacy of Helicobacter pylori infection compared to the control group (P>0.05). Conclusion: The combined application of Bifidobacterium Triple Bioactive Powder on the basis of quadruple therapy is beneficial for inhibiting the inflammatory response of peptic ulcer wounds, increasing the level of growth factors, improving the structure of gut microbiota, and creating favorable conditions for ulcer healing, which is worthy of clinical promotion.