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湿润烧伤膏治疗创伤性鼓膜穿孔的疗效分析
Efficacy Analysis of MEBO Ointment in Treating Traumatic Tympanic Membrane Perforation

孙丰林,夏倩,王慧忠,张增,王卫国.湿润烧伤膏治疗创伤性鼓膜穿孔的疗效分析[J].中国烧伤创疡杂志,2012,24(1):67~70.

DOI：10.3969/j.issn.1001-0726.[year].[issue].[sequence]

英文关键词:Tympanic Membrane Perforation Treatment MEBO Ointment

基金项目:

作者	单位
孙丰林	255031 山东淄博，淄博市中心医院耳鼻咽喉头颈外科
夏倩	255031 山东淄博，淄博市中心医院耳鼻咽喉头颈外科
王慧忠	255031 山东淄博，淄博市中心医院耳鼻咽喉头颈外科
张增	255031 山东淄博，淄博市中心医院耳鼻咽喉头颈外科
王卫国	255031 山东淄博，淄博市中心医院耳鼻咽喉头颈外科

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中文摘要:

目的　探讨湿润烧伤膏（ＭＥＢＯ）对创伤性鼓膜穿孔愈合的影响。方法　将２００８年１月至２０１１年３月间收治的１３６例（１３６耳）创伤性鼓膜穿孔中的６８例（６８耳）采用ＭＥＢＯ油纱贴补穿孔治疗，平均３ｄ～７ｄ更换１次贴补油纱，并行电子耳内镜拍照，对穿孔愈合过程进行形态学观察。结果　随访３个月，采用ＭＥＢＯ油纱贴敷治疗的６８耳小、中、大穿孔治愈率分别为１００％、１００％、８３.３３％；愈合时间分别为：（９.０±１.８）ｄ、（１２.０±２.２）ｄ、（２０.０±３.６）ｄ，其中大穿孔１例未愈，１例失访。结论　ＭＥＢＯ能有效地促进鼓膜上皮层、纤维层增殖，加快鼓膜穿孔愈合，并有较好的抗感染作用。

英文摘要:

Objective: To investigate the healing effect of MEBO Ointment in the treatment of traumatic tympanic membrane perforation. Methods:136 cases with traumatic tympanic membrane perforation were admitted from January 2008 to March 2011 and were randomly divided into a treatment group (N=68) who used the gauze soaking with MEBO Ointment as a cover, and a control group (N=68) without any interventions. Results: The three-month follow-up showed that in the treatment group, the curative rates of the small-, medium- and large perforation were 100%, 100% and 83.33% respectively while the healing times for each sub-group were (9.0±1.8) days, (12.0±2.2) days, (20.0±3.6) days respectively. In the sub-group of large perforation, there was one non-healed case and one case that dropped out of the follow-up. On the contrary, in the control group, the curative rates of the small-, medium- and large perforation were 85%, 75%, 50% respectively. There were 6, 4 and 6 non-healed cases in sub-groups of small-, medium- and large perforation. Moreover, 2 non-healed cases in each sub-group were caused by a middle ear infection. The healing times for each sub-group were (14.0±1.6) days, (23.0±2.6) days, (36.0±2.4) days respectively. Conclusion: MEBO Ointment can effectively promote the reconstruction of the epithelial layer and fibrous layer of tympanic membrane and speed up the healing rate of tympanic membrane perforation. Meanwhile, an anti-inflammatory effect of MEBO Ointment was observed.