| 鲍琳琳,周 慧.儿童溃疡性结肠炎复发的危险因素分析[J].中国烧伤创疡杂志,2025,(4):329~332. |
| DOI： |
| 中文关键词: 溃疡性结肠炎 儿童 复发 危险因素 影响因素 |
| 英文关键词:Ulcerative colitis Children Recurrence Risk factors Influencing factor |
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| 中文摘要: |
| 【摘要】 目的 分析儿童溃疡性结肠炎复发的危险因素。 方法 选取 2021 年 12 月至 2023 年 12 月汶上县人民医院收治的 240 例溃疡性结肠炎患儿作为研究对象, 收集患儿性别、年龄等基础情况, 白细胞介素-6 (IL-6) 等实验室检测指标水平, 以及复发情况等资料, 并根据治疗后 1 年内是否复发分为复发组和未复发组, 分析两组患儿相关资料, 探讨引起溃疡性结肠炎复发的独立危险因素。 结果 治疗后 1 年内, 240 例溃疡性结肠炎患儿共复发 65 例 (27.08%), 设为复发组; 未复发 175 例 (72.92%), 设为未复发组。 多因素 Logistic 回归分析结果显示, 饮食习惯、病情严重程度、主要照顾者文化程度与自我效能以及血清 IL-6、肿瘤坏死因子-α (TNF-α)、C 反应蛋白 (CRP)、超氧化物歧化酶 ( SOD) 水平是儿童溃疡性结肠炎复发的独立影响因素 ( 95% CI 为 1.031 ~ 3.833、1.252 ~ 51.271、1.038 ~ 8.927、0.079 ~ 0.832、1.297 ~ 10.115、1.080 ~ 7.637、1.128 ~ 6.406、0.058 ~ 0.799, P= 0.040、0.028、0.042、0.023、0.014、0.034、0.025、0.021)。 结论 儿童溃疡性结肠炎的复发与饮食习惯、病情严重程度、主要照顾者照顾情况以及血清 IL-6、TNF-α、CRP、SOD 水平密切相关。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the risk factors for recurrence of ulcerative colitis in children. Methods 240 children with ulcerative colitis admitted to Wenshang People’s Hospital from December 2021 to December 2023 were selected as research subjects. Data were collected including sex, age, laboratory indexes such as interleukin-6 (IL-6), and recurrence condition. The children were divided into the recurrence group and the non-recurrence group based on recurrence within 1 year after treatment. The related data of the two groups were analyzed to study the independent risk factors for recurrence of ulcerative colitis. Results Within 1 year after treatment, of the 240 children with ulcerative colitis, 65 cases (27.08%) developed recurrence, being set as recurrence group, and the other 175 cases ( 72.92%) without recurrence were set as non-recurrence group. Multivariate Logistic regression analysis showed that dietary habits, disease severity, education level and self-efficacy of the primary caregiver, and serum levels of IL-6, tumor necrosis factor-α ( TNF-α), C-reactive protein (CRP), superoxide dismutase (SOD) were independent influencing factors for the recurrence of ulcerative colitis ( 95% CI: 1.031 - 3.833, 1.252 - 51.271, 1.038 - 8.927, 0.079 - 0.832, 1.297 - 10.115, 1.080 - 7.637, 1.128-6.406, 0.058-0.799, P= 0.040, 0.028, 0.042, 0.023, 0.014, 0.034, 0.025 and 0.021). Conclusion The recurrence of ulcerative colitis in children is closely associated with dietary habits, disease severity, education level and self-efficacy of the primary caregiver, and serum levels of IL-6, TNF-α, CRP, SOD. |
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