| 吴高洁,李 敏.柠檬酸盐抗凝在烧伤脓毒症连续性血液净化中的应用效果分析[J].中国烧伤创疡杂志,2025,(4):280~284. |
| DOI： |
| 中文关键词: 柠檬酸盐 烧伤 脓毒症 抗凝 连续性血液净化 |
| 英文关键词:Citrate anticoagulation Burn Sepsis Anticoagulation Continuous blood purification |
| 基金项目: |
|
| 摘要点击次数: 18 |
| 全文下载次数: 41 |
| 中文摘要: |
| 【摘要】 目的 分析柠檬酸盐抗凝在烧伤脓毒症连续性血液净化中的应用效果。 方法 选取 2021 年 6 月至 2024 年 6 月商丘市第一人民医院收治的 100 例烧伤脓毒症患者作为研究对象, 按照连续性血液净化中不同抗凝方式将其分为柠檬酸组 (50 例) 与低分子肝素组 (50 例)。柠檬酸组患者连续性血液净化中应用柠檬酸盐抗凝, 低分子肝素组患者连续性血液净化中应用低分子肝素抗凝, 对比两组患者凝血功能、血液净化效果及炎症指标水平与不良事件发生情况。结果 治疗 24 h 后, 柠檬酸组患者活化部分凝血活酶时间 (APTT)、凝血酶原时间 (PT) 均明显短于低分子肝素组, 纤维蛋白原 (FIB) 水平明显低于低分子肝素组 (t = 11.253、6.510、6.498, P均<0.001); 治疗 48 h 后, 柠檬酸组患者血尿素氮 ( BUN)、乳酸 ( LAC)、白细胞介素-6 ( IL-6)、降钙素原 (PCT)、肿瘤坏死因子-α (TNF-α) 水平均明显低于低分子肝素组 ( t = 7.355、15.566、12.360、7.415、7.885, P 均<0.001); 柠檬酸组患者不良事件发生率明显低于低分子肝素组 ( χ 2 = 5.983, P = 0.014)。 结论 与低分子肝素抗凝相比, 给予烧伤脓毒症患者连续性血液净化过程中应用柠檬酸盐抗凝更有利于改善凝血功能、提高血液滤过效果、降低炎症反应程度, 且能够减少出血等不良事件的发生风险。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the clinical efficacy of citrate anticoagulation in continuous blood purification for burn sepsis. Methods 100 patients with burn sepsis admitted to Shangqiu First People’s Hospital from June 2021 to June 2024 were enrolled as research subjects and divided into the citrate group ( n = 50) and the low molecular weight heparin group (n = 50) according to different anticoagulation methods in continuous blood purification. Patients in the citrate group underwent continuous blood purification with citrate anticoagulation, while those in the low molecular weight heparin group underwent continuous blood purification with low molecular weight heparin anticoagulation. Coagulation function, blood purification effect, inflammatory factor levels, and the occurrence of adverse reactions were compared between the two groups. Results After 24 hours of treatment, the activated partial thromboplastin time (APTT) and prothrombin time (PT) of patients in the citrate group were significantly shorter, and the fibrinogen ( FIB) level in the citrate group was significantly lower than the low molecular weight heparin group ( t = 11.253, 6.510 and 6.498, all P<0.001). After 48 hours of treatment, the levels of blood urea nitrogen ( BUN), lactic acid ( LAC), interleukin?6 ( IL?6), procalcitonin(PCT), and tumor necrosis factor?α (TNF?α) of patients in the citrate group were significantly lower than the low molecular weight heparin group (t = 7.355, 15.566, 12.360, 7.415 and 7.885, all P<0.001). The incidence of adverse reactions in the citrate group was significantly lower than the low molecular weight heparin group ( χ 2 = 5.983, P = 0.014). Conclusion Compared with low molecular weight heparin anticoagulation, citrate anticoagulation in continuous blood purification for burn sepsis is more beneficial for improving coagulation function, enhancing blood filtration effect, decreasing inflammatory responses and reducing the risk of bleeding and other adverse reactions. |
|
|
|
|
