| 张 静,周露露,张胡爽.湿润烧伤膏在儿童深Ⅱ度烧伤创面中的应用[J].中国烧伤创疡杂志,2025,(3):206~210. |
| DOI： |
| 中文关键词: 儿童 深Ⅱ度烧伤 湿润烧伤膏 炎症 疼痛 瘢痕增生 |
| 英文关键词:Children Deep Ⅱ degree burns MEBO Inflammation Pain Scar hyperplasia |
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| 中文摘要: |
| 【摘要】 目的 分析湿润烧伤膏在儿童深Ⅱ度烧伤创面中的应用效果。 方法 选取 2020 年 10 月至 2023 年 10 月南阳市中心医院收治的60例深Ⅱ度烧伤患儿作为研究对象, 按照不同治疗方法将其分为研究组 (30 例) 和对照组 (30例)。研究组患儿局部创面采用湿润烧伤膏治疗, 对照组患儿局部创面采用重组人表皮生长因子联合纳米银医用抗菌敷料治疗, 对比观察两组患儿炎症因子与致痛因子水平、创面疼痛程度、创面愈合率以及愈后皮肤瘢痕增生程度。结果 治疗 10 d 后, 研究组患儿血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α (TNF-α)、白细胞介素-8 (IL-8) 以及神经肽 Y (NPY)、5-羟色胺 (5-HT)、前列腺素 E2 (PGE2 ) 水平均明显低于对照组 (t = 13.201、10.902、9.311、15.222、11.503、8.328、8.832, P 均<0.001); 治疗 5、10 d 后, 研究组患儿创面疼痛程度均明显轻于对照组 ( t = 3.981、7.636, P 均<0.001); 治疗7、14 d 后, 研究组患儿创 面愈合率均明显高于对照组 (t = 7.604、6.785, P 均<0.001); 创面愈合后6个月, 研究组患儿愈后皮肤瘢痕增生程度明显轻于对照组 (t = 5.190, P<0.001)。 结论 与重组人表皮生长因子联合纳米银医用抗菌敷料治疗相比, 湿润烧伤膏更能明显抑制深Ⅱ度烧伤患儿炎症因子与致痛因子的合成及释放, 减轻炎症反应及疼痛, 加快创面愈合, 降低瘢痕增生程度。 |
| 英文摘要: |
| 【Abstract】 Objective To analyze the clinical efficacy of moist exposed burn ointment (MEBO) in children with deep Ⅱ degree burns. Methods Sixty children with deep Ⅱ degree burns admitted to Nanyang Central Hospital from October 2020 to October 2023 were enrolled and divided into study group ( n = 30) and control group ( n = 30) based on different treatment methods. The local wounds of children in the study group were treated with MEBO, while the local wounds of children in the control group were treated with recombinant human epidermal growth factor combined with nano silver medical antibacterial dressing. Levels of inflammatory and pain-inducing factors, wound pain severity, wound healing rate, and scar hyperplasia of healed skin of children were compared between the two groups. Results After 10 days of treatment, the serum levels of C-reactive protein ( CRP), interleukin-6 ( IL-6), tumor necrosis factor-α ( TNF-α), interleukin-8 (IL-8), and neuropeptide Y (NPY), 5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2 ) of children in the study group were significantly lower than those in the control group ( t = 13.201, 10.902, 9.311, 15.222, 11.503, 8.328 and 8.832, all P<0.001). After 5 and 10 days of treatment, the wound pain severity of children in the study group was significantly lighter than that in the control group (t = 3.981 and 7.636, both P<0.001). After 7 and 14 days of treatment, the wound healing rate of children in the study group was significantly higher than that in the control group (t = 7.604 and 6.785, both P<0.001). Six months after wound healing, the scar hyperplasia of the healed skin in the study group was obviously milder than that in the control group ( t = 5.190, P<0.001). Conclusion Compared with recombinant human epidermal growth factor combined with nano silver medical antibacterial dressing, MEBO can obviously inhibit the synthesis and release of inflammatory and pain-inducing factors in children with deep Ⅱ degree burns, alleviate inflammation and pain, accelerate wound healing, and reduce the degree of scar hyperplasia. |
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