| Objective To investigate the clinical efficacy of negative pressure closed drainage combined with autologous adipose-derived stem cells in the treatment of chronic refractory wounds in the elderly. Methods A total of 100 elderly patients with chronic refractory wounds admitted from September 2021 to September 2024 were selected as the study subjects, and they were randomly divided into the study group and the control group, with 50 cases in each group. The patients in the study group were treated with negative pressure occlusion drainage combined with autologous adipose-derived stem cells, and the patients in the control group were treated with negative pressure occlusion and drainage, and the levels of inflammation, growth factors and granulation tissue were compared between the two groups. Results After treatment 7 and 14, the levels of IL-1β and TNF-α in the study group were significantly lower than those in the control group, and the levels of FGF and VEGF were significantly higher than those in the control group (P<0.05), and the granulation tissue growth in the study group was significantly better than that in the control group (P<0.05) after treatment 14. Conclusion Negative pressure closed drainage combined with autologous adipose-derived stem cells is more beneficial to improve the inflammatory response, increase the level of growth factors, and promote the growth of granulation tissue in elderly patients with chronic refractory wounds. |
