• 凝血酶联合奥美拉唑镁治疗胃溃疡伴胃出血疗效分析
  • Clinical Efficacy of Thrombin Combined with Omeprazole Magnesium in the Treatment of Gastric Ulcer Complicated with Gastric Bleeding
  • 王保雨,张会杰.凝血酶联合奥美拉唑镁治疗胃溃疡伴胃出血疗效分析[J].中国烧伤创疡杂志,2024,(5):410~412.
    DOI:
    中文关键词:  胃溃疡  胃出血  凝血酶  奥美拉唑镁  症状缓解时间  胃酸
    英文关键词:Gastric ulcer  Gastric bleeding  Thrombin  Omeprazole magnesium  Symptom relief time  Gastric acid
    基金项目:
    作者单位
    王保雨 471300 河南 洛阳, 洛阳仁大医院急诊科 
    张会杰  
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    中文摘要:
          【摘要】 目的 分析探讨凝血酶联合奥美拉唑镁治疗胃溃疡伴胃出血的临床效果。 方法 选取 2021 年 1 月至 2022 年 6 月洛阳仁大医院收治的 80 例胃溃疡伴胃出血患者作为研究对象, 根据不同治疗方法将其分为联合组(46 例) 和常规组 (34 例), 联合组患者在基础治疗基础上应用凝血酶与奥美拉唑镁联合治疗, 常规组患者在基础治疗基础上单纯应用凝血酶治疗, 对比观察两组患者主要临床症状缓解时间、胃液 pH 值以及临床疗效。 结果 联合组患者便血/ 呕血缓解时间与常规组无明显差异 (t = 1.240, P = 0.219), 而腹胀、腹痛以及嗳气缓解时间均明显短于常规组 (t = 7.503、5.911、9.253, P 均<0.001); 治疗 14 d 后, 联合组患者胃液 pH 值明显高于常规组 (t = 12.456, P<0.001); 治疗 14 d 后, 联合组患者中显效 36 例、有效 8 例、无效 2 例, 明显优于常规组患者的显效 16 例、有效 11 例、无效 7 例 (Z= -3.013, P= 0.003)。 结论 凝血酶联合奥美拉唑镁能够显著提升胃溃疡伴胃出血的治疗效果, 缩短主要临床症状缓解时间, 有效调节胃液 pH 值, 临床应用价值较高。
    英文摘要:
          【Abstract】 Objective To analyze the clinical efficacy of thrombin combined with omeprazole magnesium in the treatment of gastric ulcer complicated with gastric bleeding. Methods 80 patients with gastric ulcer complicated with gastric bleeding, admitted to Luoyang Renda Hospital from January 2021 to June 2022, were enrolled as research subjects and were divided into the combination group ( n = 46) and the routine group ( n = 34) according to different treatment methods they received. On the basis of symptomatic treatments, patients in the combination group were treated with thrombin combined with omeprazole magnesium, whereas patients in the routine group were treated with thrombin alone. The main clinical symptom relief time, gastric pH value, and clinical efficacy were compared between the two groups. Results There was no significant difference in the relief time of hematochezia / hematemesis between the combination group and the routine group (t = 1. 240, P = 0. 219). However, the relief times for abdominal distension, abdominal pain, and belching were significantly shorter in the combination group (t = 7. 503, 5. 911 and 9. 253, all P<0. 001). After 14 days of treatment, the gastric pH value in the combination group was significantly higher than that in the routine group ( t = 12. 456, P<0. 001).After 14 days of treatment, the clinical efficacy was evaluated as markedly effective in 36 cases, effective in 8 cases and ineffective in 2 cases in the combination group, which was much better than that in the routine group (Z = -3. 013, P =0. 003) - markedly effective in 16 cases, effective in 11 cases, and ineffective in 7 cases. Conclusion Thrombin combined with omeprazole magnesium can significantly improve the treatment effect of gastric ulcer complicated with gastric bleeding, shorten the relief time of main clinical symptoms, and effectively regulate gastric pH value, presenting high value of clinical application.