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湿润烧伤膏对糖尿病足创面组织中MMP-2、MMP-9、Bcl-2、Bax水平的影响
Influence of MEBO on the Levels of MMP-2, MMP-9, Bcl-2 and Bax in Diabetic Foot Wound Tissues

韩芳,侯献敏.湿润烧伤膏对糖尿病足创面组织中MMP-2、MMP-9、Bcl-2、Bax水平的影响[J].中国烧伤创疡杂志,2024,(2):85~89.

DOI：

中文关键词: 湿润烧伤膏负压封闭引流糖尿病足基质金属蛋白酶-2 B 细胞淋巴瘤-2 基质金属蛋白酶-9 Bcl-2 相关 X 蛋白

英文关键词:MEBO Vacuum sealing drainage Diabetic foot Matrix metalloproteinase-2 B-cell lymphoma-2 Matrix metalloproteinase-9 Bcl-2 associated X protein

基金项目:

作者	单位
韩芳	450007 河南郑州, 郑州大学附属郑州中心医院创面修复中心
侯献敏

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中文摘要:

【摘要】目的探讨湿润烧伤膏(MEBO)对糖尿病足创面组织中基质金属蛋白酶(MMP)-2、MMP-9、B细胞淋巴瘤-2(Bcl-2)、Bcl-2相关X蛋白(Bax)水平的影响。方法选取2020年5月至2022年5月郑州大学附属郑州中心医院收治的55例糖尿病足患者作为研究对象,按照不同治疗方法将其分为MEBO组(35例)和VSD组(20例),MEBO组患者局部创面采用MEBO治疗,VSD组患者局部创面采用负压封闭引流(VSD)治疗,对比观察两组患者创面面积,创面组织中MMP-2、MMP-9、Bcl-2、Bax水平及临床疗效。结果治疗第7、21天,MEBO组患者创面面积均明显小于VSD组(t=2.719、5.268,P=0.009、P<0.001),创面组织中MMP-2、MMP-9、Bax水平均明显低于VSD组(MMP-2:t=2.138、2.202,P=0.037、0.032;MMP-9:t=2.129、2.476,P=0.038、0.017;Bax:t=3.623、3.038,P=0.001、0.004),Bcl-2水平均明显高于VSD组(t=2.040、3.054,P=0.046、0.004);治疗21d后,MEBO组患者中显效23例、有效10例、无效2例,明显优于VSD组患者的显效8例、有效7例、无效5例(Z=-2.126,P=0.033)。结论MEBO可通过降低糖尿病足创面组织中MMP-2、MMP-9、Bax水平以及提高Bcl-2水平促进创面愈合。

英文摘要:

【Abstract】 Objective To study the influence of MEBO on the levels of matrix metalloproteinase (MMP) -2,MMP-9, B-cell lymphoma-2 (Bcl-2), Bcl-2 associated X protein ( Bax) in diabetic foot wound tissues. Methods 55 patients with diabetic foot, admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from May 2020 to May 2022, were enrolled as research subjects, and divided into MEBO group ( n = 35) and VSD group ( n = 20) based on the different treatments they received. The wounds of patients in the MEBO group were treated with MEBO, whereas the wounds of patients in the VSD group were treated with vacuum sealing drainage (VSD). The wound areas, the levels of MMP-2, MMP-9, Bcl-2 and Bax in wound tissues, and clinical efficacy were compared between the two groups. Results Respectively on day 7 and day 21 of treatment, compared with VSD group, the wound area of patients in the MEBO group wassignificantly smaller (t = 2.719 and 5.268, P= 0.009, P<0.001), the levels of MMP-2, MMP-9 and Bax in wound tissues were all obviously lower (MMP-2: t = 2.138 and 2.202, P= 0.037 and 0.032; MMP-9: t = 2.129 and 2.476, P = 0.038 and 0.017; Bax: t = 3.623 and 3.038, P = 0.001 and 0.004), and the levels of Bcl-2 in wound tissues were obviously higher (t = 2.040 and 3.054, P = 0.046 and 0.004). After 21 days of treatment, the clinical efficacy was evaluated as markedly effective in 23 cases, effective in 10 cases and ineffective in 2 cases in the MEBO group, which was obviously superior to that in the VSD group (Z= -2.126, P= 0.033) - markedly effective in 8 cases, effective in 7 cases and ineffective in 5 cases. Conclusion MEBO can promote the healing of diabetic foot wounds by reducing the levels of MMP-2, MMP-9 and Bax while elevating the level of Bcl-2 in diabetic foot wound tissues.